By examining a huge collection of datasets regarding the molecular response to nanomaterials, they have disclosed an ancestral epigenetic mechanism of defense that describes how different species, from humans to simpler creatures, will adapt to this kind of exposure.

The project was headed by Doctoral Researcher Giusy del Giudice and Professor Dario Greco at the Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Tampere University, Finland, in partnership with an interdisciplinary group from Finland, Poland, Ireland, Cyprus, South Africa, UK, Greece, and Estonia—including Associate Professor Vladimir Lobaskin from UCD School of Physics, University College Dublin, Ireland.

The study entitled, “An ancestral molecular response to nanomaterial particulates” was reported in the Nature Nanotechnology journal on May 2023.

We have demonstrated for the first time that there is a specific response to nanoparticles, and it is interlinked to their nano-properties. This study sheds light on how various species respond to particulate matter in a similar manner. It proposes a solution to the one-chemical-one-signature problem, currently limiting the use of toxicogenomic in chemical safety assessment.

Dario Greco, Professor and Director, Finnish Hub for Development and Validation of Integrated Approaches, Tampere University

source:

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